25OH Vitamin D2/D3
Test Code: 3002CPT: 82306
|Tests Included||25-OH Vitamin D, Total; Vitamin D, 25-OH, D3; Vitamin D, 25-OH, D2|
|Use||Vitamin D levels are monitored for a number of uses ranging from dietary absorbtion, parathyroid function, bone weakness/malformation, metabolism of calcium, and to help with measuring Vitamin D treatment effectiveness|
|Clinical Utility||Vitamin D is a fat soluble vitamin that is important in the regulation of calcium and phosphorous in the body. Vitamin D deﬁciency has been linked to rickets, osteoporosis and osteomalacia. It has also been associated with many other diseases such as cancer, cardiovascular disease, diabetes, and autoimmune disorders. Low levels result from dietary deficiency, poor absorption, or sterol metabolism blockage in the liver. High levels may lead to hypercalcemia.|
|Intended Patient Population||18+ and Older Adult Males & Females|
|Sample||Serum, Plasma, Whole Blood|
|Tube||Red, Green, Tiger|
|Volume||100uL Whole Blood|
|Min Sample Volume||0.05 mLs|
|Reference Ranges||Total Vit D - M & F ≥ 18 yrs old; 30-50 ng/mL|
|Analytical Measurement Range||1.5-100.00 ng/mL|
|Clinical Values||> 80 ng/mL|
|Test Turnaround Time||5 Days|
|Limitations||Values of vitamin D vary with exposure to sunlight and dietary supplementation.|
|Shipping Requirements||Room Temperature|
|Specimen Stability||8 Days Room Temperature|
|Reject Criteria||Gross Hemolysis, Expired Sample, Insufficient Quantity|
|Laboratory Developed Test (LDT)||Yes|
|CMS Guidance||LCD L36692|
|References||1. Holick MF (2007) Vitamin deﬁciency. N Engl J Med 357: 266 -281.
2. Abrams SA (2011) Vitamin D supplementation during pregnancy. J Bone
Mineral Res 26: 2338 – 2340.
3. Holick MF et al (2011) Evaluation, treatment and prevention of vitamin D deﬁciency: An endocrine society clinical practice guideline. J Clin Endocrinol Metab 96: 1911 -1930.
4. Watts NB, Bilezikian JP, Camacho PM, et al. American Association of Clinical Endocrinologists medical guidelines for clinical practice for the diagnosis and treatment of postmenopausal osteoporosis. Endocr Pract. 2010;16(Suppl 3):1-37.