Test Code: 4003CPT: 83002
|Use||Luteinizing hormone (LH) is a gonadotropin released by the pituitary glands that acts synergistically with follicle stimulating hormone (FSH) to stimulate testosterone production in males and to enhance estradiol production in women (secreted by maturing follicles).|
|Clinical Utility||The ratio of LH/FSH has been used to assist in the diagnosis of polycystic ovary disease. Low concentrations of LH and FSH may indicate pituitary failure while elevated concentrations of LH and FSH along with decreased concentrations of gonadal steroids may indicate gonadal failure (menopause, ovariectomy, premature ovarian syndrome, Turners Syndrome).1
Low concentrations of gonadotropin are usually observed in females taking oral steroid based contraceptives.2 In the male, elevated hLH and hFSH with low concentrations of gonadal steroids may indicate testicular failure or anorchia. In Klinefelter's syndrome hLH may be elevated due to Sertoli cell failure.3
|Intended Patient Population||18+ and Older Adult Males & Females|
|Patient Preparation||None Specified|
|Tube||Red, Green, Tiger|
|Volume||4mL Whole Blood (1mL Serum/Plasma)|
|Min Sample Volume||0.5 mLs|
|Reference Ranges||M ≥ 18 yrs old; 1.2-8.6 mIU/mL
F Mid-Follicular ≥ 18 yrs old; 2.1-10.9 mIU/mL
F Mid-Cycle Peak ≥ 18 yrs old; 19.2-103 mIU/mL
F Mid-Luteal ≥ 18 yrs old; 1.2-12.9 mIU/mL
F Post-Menopausal ≥ 18 yrs old; 10.9-58.6 mIU/mL
|Analytical Measurement Range||0.1-250.0 mIU/mL|
|Test Methodology||Chemiluminescent Immunoassay|
|Test Turnaround Time||7 Days|
|Specimen Stability||7 Days RT
7 Days RF
|Laboratory Developed Test (LDT)||Yes|
|References||1. Hall JE. Polycystic ovarian disease as a neuroendocrine disorder of the female reproductive axis. In Endocrinology and Metabolism Clinics of North America 1993; Edited by Veldhuis JD, Philadelphia, PA: W.B. Saunders Co. 22 (1): 75-92.
2. Bonnar J. The hypothalmus and reproductive function. In The Medical Annual 1973; Edited by Scott RB and Walker RM, Bristol, England, J. Wright and Sons, 251-258.
3. Tietz Textbook of Clinical Chemistry. 1994. Second edition. Edited by Burtis CA and Ashwood ER, Philadelphia, PA: W. B. Saunders Co. 1846-1850.