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Albumin

 

Insource Diagnostics

Albumin

Alternative Names
  • ALB
  • Albumin S
  • Hypoalbuminemia
  • Nephrotic Syndrome

Test Code: 4500

CPT: 82040
Tests Included Albumin
Use Assement of nutritional status as well as chronic diseases in the kidney and liver.  Measurements of albumin concentrations are also vital to the understanding the interpretation of calcium and magnesium levels.
Clinical Utility Albumin is the most abundant protein in human plasma, representing 55-65% of the total protein. Its primary biological functions are to transport and store a wide variety of ligands, to maintain the plasma oncotic pressure and to serve as a source of endogenous amino acids. Albumin binds and solubilises non-polar compounds such as plasma bilirubin and long-chain fatty acids as well as binding numerous pharmaceuticals

Hypoalbuminemia may be caused by impaired synthesis e.g. in liver disease or in protein defcient diets; increased catabolism as a result of tissue damage and inflammation; reduced absorption of amino acids caused by malabsorption syndromes or malnutrition; protein loss to the exterior as observed in nephrotic syndrome, enteropathy or burns; and altered distribution e.g. in ascites. Severe hypoalbuminemia results in a serious imbalance of intravascular oncotic pressure causing the development of edema

Hyperalbuminemia is infrequent and is caused by severe dehydration and excessive venous stasis.
Intended Patient Population 18+ and Older Adult Males & Females
Patient Preparation None Specified
Sample Serum, Plasma
Tube Red, Green, Tiger 
Volume 4mL Whole Blood (1mL Serum/Plasma)
Min Sample Volume 0.1 mLs
Reference Ranges M & F ≥ 18 yrs old; 3.5-5.2 g/dL
Analytical Measurement Range 2.4-7.3 g/dL
Critical Values ≤ 1.5 or ≥  8.0 g/dL
Units g/dL
Test Methodology Quantitative Spectrophotometry
Test Turnaround Time 1 Day
Limitations In very rare cases Gammopathy, especially monoclonal IgM (Waldenström's macroglobinemia), may cause unreliable
results
Shipping Refrigerated
Specimen Stability 6 Days RT
6 Days RF
Reject Criteria Icterus, Gross Hemolysis
Laboratory Developed Test (LDT) Yes
Laboratory Developed Test (LDT) Yes
CMS Guidance None
References 1. Tietz Textbook of Clinical Chemistry. Edited by CA Burtis, ER Ashwood. Philadelphia, WB Saunders Company, 1999
2. "High Glycated Albumin and Mortality in Persons with Diabetes Mellitus on Hemodialysis" Clinical Chemistry Vol. 63, Issue 2 February 2017