Protein, Total (TP)

Alternative Names
  • TP

Test Code: 4506

CPT: 84155
Tests Included Protein
Use Measurements of total protein are used in the diagnosis and treatment of a variety of diseases involving the liver, kidney, or bone marrow as well as other metabolic and nutritional disorders.
Clinical Utility The total serum protein is the sum of all circulating proteins and is a major component of blood. A increase of serum total protein from the reference interval indicates the presence of dysproteinemia or a disorder in water balance. Both conditions can be distinguished by additional  performance of serum protein electrophoresis and the determination of haematocrit. A decresed total protein can result during pregnancy or when receiving intravenous fluids.  In some cases cirrhosis or other liver disease, including chronic alcoholism can also lead to reduced total protein. Crohn's disease and chronic ulcerative colitis, starvation, malabsorption or malnutrition, will also lead to lowered measured values.
Intended Patient Population 18+ and Older Adult Males & Females
Patient Preparation None Specified
Sample Serum, Plasma
Tube Red, Green, Tiger
Volume 4mL Whole Blood (1mL Serum/Plasma)
Min Sample Volume 0.1 mLs
Reference Ranges M & F ≥ 18 yrs old; 6.6-8.3 g/dL
Analytical Measurement Range 3.0-11.0 g/dL
Critical Values ≤ 4.0 ≥ 11.0 g/dL
Units g/dL
Test Methodology Quantitative Spectrophotometry
Test Turnaround Time 1 Day
Limitations Plasma samples generally yield values slightly higher than serum samples due to the presence of fibrinogen in the plasma. Experimental data showed an average increase of 0.3 g/dL with a range 0.1 to 0.5 g/dL.
Shipping Requirements Refrigerated
Specimen Stability 7 Days RT
7 Days RF
Reject Criteria Icterus, Gross Hemolysis
Laboratory Developed Test (LDT) Yes
CMS Guidance None
  1. Tietz Textbook of Clinical Chemistry. Edited by CA Burtis, ER Ashwood. Philadelphia, WB Saunders Company, 1999

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