LD-H

Alternative Names
  • LD
  • LDH
  • Lactate Dehydrogenase

Test Code: 4507

CPT: 83615
Tests Included LDH
Use Elevations in serum lactate dehydrogenase (LD) occur from myocardial infarction, liver disease, pernicious and megaloblastic anemias, pulmonary emboli, malignancies, and muscular dystrophy.1
Clinical Utility A combined analysis of LD and CK (creatine kinase) isoenzymes provides a definite diagnosis of acute myocardial infarction.2
Intended Patient Population 18+ and Older Adult Males & Females
Patient Preparation None
Sample Serum, Plasma
Tube Red, Green, Tiger
Volume 4mL Whole Blood (1mL Serum/Plasma)
Min Sample Volume 0.5 mLs
Reference Ranges M & F ≥ 18 yrs old; 140-271 U/L
Analytical Measurement Range 25-1200 U/L
Critical Values ≥ 400.0 U/L
Units U/L
Test Methodology Lactate-Pyruvate (NAD); IFCC
Test Turnaround Time 2 Days
Limitations Even minimal hemolysis causes significant increase in LD due to high levels of this enzyme in red cells.1
Shipping Requirements Refrigerated
Specimen Stability N/A
Reject Criteria Gross Hemolysis, Gross Lipemia
Laboratory Developed Test (LDT) Yes
CMS Guidance None
References
  1. Tietz, N.W., Fundamentals of Clinical Chemistry, 3rd Edition, W.B. Saunders, 1987.
  2. Roe, C.R., Limbird, L.E., Wagner, G.S. and Nerenberg, S.T., J Lab Clin Med, 80: 577, 1972.

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