Alternative Names
  • ALT
  • GPT
  • SGPT
  • Transaminase
  • SGPT
  • Alanine transaminase
  • AST/ALT ratio
  • Serum glutamic-pyruvic transaminase

Test Code: 4501

CPT: 84460
Tests Included Alanine Aminotransferase
Use Alanine aminotransferase (ALT) measurements are useful in the diagnosis and treatment of certain liver diseases (e.g., viral hepatitis and cirrhosis) and heart disease. Often ordered in conjuction wiht AST to determine whether the source of the abnormal AST is liver or heart.
Clinical Utility ALT is an enzyme involved in amino acid metabolism and is therefore found in many tissues. The highest levels of ALT are found in the liver and kidney tissues. Markedly elevated serum ALT levels may be found in a variety of diseases which involve the liver, such as hepatitis, mononucleosis and cirrhosis. These very high levels of ALT are not usually observed in other diseases processes, e.g. myocardial infarction, thus ALT is regarded as a reasonably specific indicator of liver disease.
Intended Patient Population 18+ and Older Adult Males & Females
Patient Preparation None Specified
Sample Serum, Plasma
Tube Red, Green, Tiger
Volume 4mL Whole Blood (1mL Serum/Plasma)
Min Sample Volume 0.1 mLs
Reference Ranges M & F ≥ 18 yrs old; 7-52 IU/L
Analytical Measurement Range 2-488 IU/L
Units IU/L
Test Methodology Quantitative Enzymatic
Test Turnaround Time 1 Day
Limitations Tissue destruction leads to the release of the intracellular enzyme into the circulating blood and elevated measurements. The use of cocaine, anabolic steroids, or ecstasy may also produce erroneous results.
Shipping Refrigerated
Specimen Stability 5 Days RT
5 Days RF
Reject Criteria Hemolysis
Laboratory Developed Test (LDT) Yes
CMS Guidance None
  1. Tietz Textbook of Clinical Chemistry. Edited by CA Burtis, ER Ashwood. Philadelphia, WB Saunders Company, 1999

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